Enhanced stem cell derived beta cell responses when cultures on matrix proteins

In our first work using stem cells we show the benefit of growing the cells on extracellular matrix. This work builds on our understanding that native beta cells require extracellular matrix to function properly.

The work was funded in part by a generous donation from John and Anne Chong.

Singh R., Cottle L., Loudovaris T., Xiao D., Yang P., Thomas HE., Kebede MA. And Thorn P (2020) Enhanced Structure and Function of Human Pluripotent Stem Cell-Derived Beta-Cells Cultured on Extracellular Matrix. Stem Cells Translational Medicine.