J Cell Science Paper published

The actin cytoskeleton has been known to be involved in insulin secretion since the 1980s. In this paper we provide evidence for a mechanism that uses the actin nucleator, Arp2/3, to envelope each fusing insulin granule and control the release of insulin. We conclude that extremely local changes in actin are critical to beta cell function and secretory control.

Ma, W., Chang, J., Tong, J., Ho, U., Yau, B., Kebede, MA. And Thorn, P. (2020) Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic beta cells to control insulin secretion. J Cell  Sci 133 jcs236794